alexa Netting neutrophils in autoimmune small-vessel vasculitis.
Pathology

Pathology

Journal of Clinical & Experimental Pathology

Author(s): Kessenbrock K, Krumbholz M, Schnermarck U, Back W, Gross WL,

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Abstract Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
This article was published in Nat Med and referenced in Journal of Clinical & Experimental Pathology

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