alexa Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus.


Biochemistry & Physiology: Open Access

Author(s): Olszewski PK, Li D, Grace MK, Billington CJ, Kotz CM,

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Abstract Ghrelin stimulates feeding when administered centrally and peripherally. The lateral hypothalamus (LH) is thought to mediate ghrelin-induced hyperphagia. Thus, we examined central mechanisms underlying feeding generated by LH ghrelin. We determined that 0.3nmol of LH-injected ghrelin was the lowest dose increasing food consumption and it induced Fos immunoreactivity (IR; a marker of neuronal activation) in feeding-related brain areas, including the hypothalamic paraventricular, arcuate, and dorsomedial nuclei, amygdala, and nucleus of the solitary tract. Also, LH ghrelin induced Fos IR in LH orexin neurons. We conclude that the LH, as part of larger central circuitry, integrates orexigenic properties of ghrelin.
This article was published in Peptides and referenced in Biochemistry & Physiology: Open Access

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