alexa Neurotoxic effects of organic solvents among workers in paint and lacquer manufacturing industry


Chemotherapy: Open Access

Author(s): Jovanovi J, Jovanovi M

Abstract Share this page

INTRODUCTION: Organic solvents are chemically different compounds with one common feature: they dissolve fats, oils, resins, cellulose acetate and cellulose nitrate, which makes them widely used in industry. Most often organic solvents are used in paint and lacquer industries, in production of pesticides, plastics, explosives, rubber, cellulose, air conditioners, in pharmaceutical industry and in leather industry. The aim of this research was to analyze the working environment and professional hazards in paint and lacquer manufacturing industry and evaluate effects of chronic exposure to mixture of organic solvents on nervous system of exposed workers. METHODOLOGY: The exposed group consisted of 50 workers professionally exposed to these noxae, while the control group consisted of 30 workers who have never been exposed to these noxae. RESULTS: Examination of working environment in departments of paint and lacquer manufacturing revealed presence of white spirit and toluene above allowed levels. Exposed workers more frequently complained of fatigue, hand numbness, enhanced excitation, and concentration difficulties, forgetfulness and headaches, than workers from the control group. Electroneurographic examination of n. medianus showed reduced motor and sensitive conduction velocity among exposed in comparison to workers from the control group. Reduced motor and sensitive conduction velocity was correlated with duration of exposure to these noxae. Terminal latency of n. medianus was statistically, significantly longer in the exposed group than in the control group. Workers in the exposed group have statistically significantly longer reaction time in response to acoustic and visual stimuli. DISCUSSION: Segmental demyelination and axonal degeneration, as forms of damage to peripheral nerves, were identified as responsible for peripheral neuropathy associated with occupational exposure to organic solvents. CONCLUSION: Results of this study show possible neurotoxic effects of noxae detected in the phase of analysis of working conditions and working environment of examined workers.

  • To read the full article Visit
  • Subscription
This article was published in Med Pregl and referenced in Chemotherapy: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version