alexa New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree.
General Science

General Science

Journal of Forensic Research

Author(s): Karafet TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL, , Karafet TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL,

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Abstract Markers on the non-recombining portion of the human Y chromosome continue to have applications in many fields including evolutionary biology, forensics, medical genetics, and genealogical reconstruction. In 2002, the Y Chromosome Consortium published a single parsimony tree showing the relationships among 153 haplogroups based on 243 binary markers and devised a standardized nomenclature system to name lineages nested within this tree. Here we present an extensively revised Y chromosome tree containing 311 distinct haplogroups, including two new major haplogroups (S and T), and incorporating approximately 600 binary markers. We describe major changes in the topology of the parsimony tree and provide names for new and rearranged lineages within the tree following the rules presented by the Y Chromosome Consortium in 2002. Several changes in the tree topology have important implications for studies of human ancestry. We also present demography-independent age estimates for 11 of the major clades in the new Y chromosome tree.
This article was published in Genome Res and referenced in Journal of Forensic Research

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