alexa New biomarkers for early detection of cardiotoxicity after treatment with docetaxel, doxorubicin and cyclophosphamide.
Clinical Sciences

Clinical Sciences

Cardiovascular Pharmacology: Open Access

Author(s): van Boxtel W, Bulten BF, MavinkurveGroothuis AM, Bellersen L, Mandigers CM, , van Boxtel W, Bulten BF, MavinkurveGroothuis AM, Bellersen L, Mandigers CM,

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Abstract OBJECTIVE: Assessing a diverse biomarker panel (NT-proBNP, TNF-α, galectin-3, IL-6, Troponin I, ST2 and sFlt-1) to detect subclinical cardiotoxicity after treatment with anthracyclines. METHODS: Of 55 breast cancer patients biomarkers were assessed and echocardiography was performed one year after treatment with anthracyclines. RESULTS: 29.1\% of patients showed abnormal biomarker levels: NT-proBNP in 18.2\%, TNF-α and Galectin-3 in 7.3\%. IL-6, troponin I, ST2 and sFlt-1 were normal in all patients. A correlation between left ventricular ejection fraction (LVEF) and NT-proBNP was observed (r = -0.564, p ≤ 0.01). CONCLUSION: The evaluated biomarkers do not contribute to early detection. Future research should focus on NT-proBNP. This article was published in Biomarkers and referenced in Cardiovascular Pharmacology: Open Access

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