alexa New generation of chitosan-encapsulated ZnO quantum dots loaded with drug: synthesis, characterization and in vitro drug delivery response.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Yuan Q, Hein S, Misra RD

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Abstract The objective of the study is to describe a new approach of combining quantum dots technology with anti-cancer drug therapy. In this regard, we communicate the preliminary research on the synthesis of blue-light emitting ZnO quantum dots (QDs) combined with biodegradable chitosan (N-acetylglucosamine) for tumor-targeted drug delivery. The results presented here indicate that the proposed new generation of QDs loaded with anti-cancer agents and encapsulated with biocompatible polymer represent a potential platform to deliver tumor-targeted drugs and document the delivery process, if desired. Non-toxic water-dispersed ZnO QDs with long-term fluorescence stability were synthesized by a chemical hydrolysis method, encapsulated with chitosan and loaded with anti-cancer drug. Chitosan enhanced the stability of the QDs because of the hydrophilicity and cationic charge of chitosan. The study points toward the application of water-dispersed ZnO QDs with long-term fluorescence stability for design of new drug release carrier. Copyright 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. This article was published in Acta Biomater and referenced in Journal of Molecular and Genetic Medicine

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