alexa New NO donors with antithrombotic and vasodilating activities, Part 24. Hydrazine derivatives.


Journal of Drug Metabolism & Toxicology

Author(s): Rehse K, Shahrouri T, Rehse K, Shahrouri T

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Abstract Suitable hydrazines like phenylhydrazine (1), N,N-dimethyl hydrazine (4), and N,N-diphenyl hydrazine (5) can be oxidized by hydrogen peroxide at pH 7.4 and 37 degrees C to nitrosohydrogen and further to nitrite and nitrate. The extent of this property is correlated with platelet aggregation inhibiting and antithrombotic effects of these compounds, suggesting that an NO mediated mechanism might be involved. All hydrazines tested and two N-ethoxycarbonyl prodrugs exhibited antihypertensive effects which were not correlated to the above properties. This is especially pronounced in hydralazine (6) and dihydralazine (7) which induced a strong decrease in blood pressure but exhibit neither antiplatelet nor antithrombotic effects. This indicates that the mechanism of the antihypertensive activity is different from that of the antiplatelet activity.
This article was published in Arch Pharm (Weinheim) and referenced in Journal of Drug Metabolism & Toxicology

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