Author(s): Karin M, Cao Y, Greten FR, Li ZW
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Abstract Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-KB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.
This article was published in Nat Rev Cancer
and referenced in Journal of Clinical & Cellular Immunology