alexa Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications.


Journal of Environmental Analytical Chemistry

Author(s): Goniewicz ML, Hajek P, McRobbie H

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Abstract BACKGROUND AND AIMS: Electronic cigarettes (EC) may have a potential for public health benefit as a safer alternative to smoking, but questions have been raised about whether EC should be licensed as a medicine, with accurate labelling of nicotine content. This study determined the nicotine content of the cartridges of the most popular EC brands in the United Kingdom and the nicotine levels they deliver in the vapour, and estimated the safety and consistency of nicotine delivery across batches of the same product as a proxy for quality control for individual brands and within the industry. METHODS: We studied five UK brands (six products) with high internet popularity. MEASUREMENTS: Two samples of each brand were purchased 4 weeks apart, and analysed for nicotine content in the cartridges and nicotine delivery in vapour. RESULTS: The nicotine content of cartridges within the same batch varied by up to 12\% relative standard deviation (RSD) and the mean difference between different batches of the same brand ranged from 1\% [95\% confidence interval (CI) = -5 to 7\%] to 20\% (95\% CI=14-25\%) for five brands and 31\% (95\% CI=21-39\%) for the sixth. The puffing schedule used in this study vaporized 10-81\% of the nicotine present in the cartridges. The nicotine delivery from 300 puffs ranged from ∼2 mg to ∼15 mg and was not related significantly to the variation of nicotine content in e-liquid (r=0.06, P=0.92). None of the tested products allowed access to e-liquid or produced vapour nicotine concentrations as high as conventional cigarettes. CONCLUSIONS: There is very little risk of nicotine toxicity from major electronic cigarette (EC) brands in the United Kingdom. Variation in nicotine concentration in the vapour from a given brand is low. Nicotine concentration in e-liquid is not well related to nicotine in vapour. Other EC brands may be of lower quality and consumer protection regulation needs to be implemented, but in terms of accuracy of labelling of nicotine content and risks of nicotine overdose, regulation over and above such safeguards seems unnecessary. © 2013 Society for the Study of Addiction. This article was published in Addiction and referenced in Journal of Environmental Analytical Chemistry

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