alexa Nicotine enhances cerebral glucose utilization in central components of the rat visual system.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): London ED, Dam M, Fanelli RJ

Abstract Share this page

Abstract The effect of nicotine in visual system components of the rat brain was examined using the 2-deoxy-D-[1-14C]-glucose ([14C]DG) technique. Nicotine was administered subcutaneously (SC) at doses of 0.1, 0.3, and 1.0 mg/kg 2 min before the infusion of the radiotracer. Local cerebral glucose utilization (LCGU) was stimulated by nicotine in a dose-dependent manner in many brain regions associated with the visual system. Increases of over 100\% were seen in the superior colliculus, nucleus of the optic tract, and portions of the accessory optic system (medial and dorsal terminal nuclei, and the inferior fasciculus). Statistically significant increases were also observed in the lateral geniculate nucleus, the lateral terminal nucleus and the cerebellum. The effects were blocked by pretreatment with mecamylamine and by enucleation. The findings lend support to the involvement of the nicotinic cholinergic system in the processing of visual information or visual-motor function.
This article was published in Brain Res Bull and referenced in Journal of Addiction Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords