alexa Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Mwenifumbo JC, Sellers EM, Tyndale RF

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Abstract Genetic variation in CYP2A6 (the main nicotine metabolizing enzyme) accounts for some, but not all, of the interindividual and interethnic variability in the rates of nicotine metabolism. We conducted a nicotine kinetic study in smokers and nonsmokers of black African descent (N=190), excluding those with common genetic variants in CYP2A6, to investigate the association of demographic variables with CYP2A6 activity (3HC/COT ratio) and nicotine disposition kinetics (estimated nicotine AUC). An additional aim was to examine whether impaired CYP2A6 activity and/or nicotine disposition kinetics were associated with lower cigarette consumption in a population of light smokers (mean
  • DOI: 10.1016/j.drugalcdep.2006.11.012
  • This article was published in Drug Alcohol Depend and referenced in Journal of Addiction Research & Therapy

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