alexa Nitric oxide is a signaling molecule in spermatozoa.
Reproductive Medicine

Reproductive Medicine

Andrology-Open Access

Author(s): Herrero MB, de Lamirande E, Gagnon C

Abstract Share this page

Abstract Low and controlled concentrations of nitric oxide play an important role in sperm physiology. Nitric oxide is produced by spermatozoa and acts as an intracellular signaling molecule in the processes of capacitation and acrosome reaction. It has been documented that during capacitation, nitric oxide interacts with the cAMP-protein kinase A pathway and also is involved in tyrosine nitration of sperm proteins. On the other hand, during the acrosome reaction, two different pathways have been postulated for nitric oxide to exert its effects. During the progesterone-induced acrosome reaction, nitric oxide stimulates a heme-containing enzyme, named cyclooxygenase with a subsequent increase in prostaglandin E(2). Furthermore, the acrosome reaction inducing effect of NO-releasing compounds occurs via an increase in cGMP levels and protein kinase G activation. Taken together, these data support a role for nitric oxide in sperm function. This review focuses on providing new evidence for the physiological role of nitric oxide (NO) on sperm function. We will first present a brief description on nitric oxide chemistry and on the events leading to sperm fertilizing ability followed by the observations obtained on the participation of NO on fertilization.
This article was published in Curr Pharm Des and referenced in Andrology-Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords