International Journal of Inflammation, Cancer and Integrative Therapy
Nitric oxide-releasing mesalamine: potential utility for treatment of inflammatory bowel disease.
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Abstract Nitric oxide can accelerate ulcer healing and exert anti-inflammatory effects. Addition of a nitric oxide-releasing moiety to mesalamine significantly boosts its anti-inflammatory activity. NO-releasing mesalamine suppresses inflammatory cytokine production and reduces leukocyte infiltration.