alexa Nitroimidazole resistance genes (nimB) in anaerobic Gram-positive cocci (previously Peptostreptococcus spp.).


Medicinal Chemistry

Author(s): Theron MM, Janse Van Rensburg MN, Chalkley LJ

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Abstract OBJECTIVES: To investigate metronidazole resistance and the prevalence of nitroimidazole (nim) genes in clinically isolated anaerobic Gram-positive cocci. METHODS: Metronidazole susceptibility was determined in 99 strains of anaerobic Gram-positive cocci and PCR amplification for the nim gene carried out on 61 strains (metronidazole MIC > or =0.5 mg/L). RESULTS: The nimB gene was detected in 34\% (21/61) of the strains. These included two highly resistant Finegoldia magna strains (MICs >128 mg/L). The nimB gene was, however, also demonstrated in 90\% (19/21) of susceptible strains. CONCLUSIONS: Although the nimB gene may be implicated in the high-level metronidazole resistance in 2 F. magna strains, the alarmingly high prevalence of the nimB gene in anaerobic Gram-positive cocci cannot be directly associated with resistance and the possibility of a silent nimB gene should be considered. This article was published in J Antimicrob Chemother and referenced in Medicinal Chemistry

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