Author(s): Ho SS, Gasser S, Ho SS, Gasser S
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Abstract RAS is constitutively active in multiple types of tumor cells. We have recently demonstrated that H-RASV12 enhances the translation of ligands for the activating immune receptor NKG2D, hence rendering cells more susceptible to natural killer (NK) cell-mediated lysis. This effect depends on MAPK and PI3K signaling, but not on the DNA damage response.
This article was published in Oncoimmunology
and referenced in Immunome Research