Author(s): Smyth MJ, Crowe NY, Hayakawa Y, Takeda K, Yagita H,
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Abstract NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.
This article was published in Curr Opin Immunol
and referenced in Clinical Depression