alexa NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
Pulmonology

Pulmonology

Journal of Pulmonary & Respiratory Medicine

Author(s): Tschopp J, Schroder K

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Abstract The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS). This article was published in Nat Rev Immunol and referenced in Journal of Pulmonary & Respiratory Medicine

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