Author(s): De Groote MA, Fang FC
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Abstract The past decade has witnessed a veritable explosion of interest in the simple molecule nitric oxide (NO) as a vasodilator, neurotransmitter, and antimicrobial agent. NO and other reactive nitrogen intermediates exhibit cytostatic or cytocidal activity against a remarkable breadth of pathogenic microorganisms. Mammalian cells, including human cells, produce nitric oxide both constitutively and inducibly in response to inflammatory stimuli. This review will provide a brief overview of current knowledge regarding the antimicrobial activity of NO and the possible importance of this activity in infection, particularly with regard to intracellular pathogens.
This article was published in Clin Infect Dis
and referenced in Clinical Microbiology: Open Access