alexa Non-apoptotic functions of apoptosis-regulatory proteins.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Galluzzi L, Kepp O, TrojelHansen C, Kroemer G

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Abstract During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.
This article was published in EMBO Rep and referenced in Journal of Cytology & Histology

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