alexa Nonfatal systemic allergic reactions induced by skin testing and immunotherapy.
Immunology

Immunology

Journal of Allergy & Therapy

Author(s): Lin MS, Tanner E, Lynn J, Friday GA Jr

Abstract Share this page

Abstract Skin testing and immunotherapy with allergens can induce systemic allergic reactions. In order to identify factors associated with systemic allergic reactions, a prospective study was conducted from 1976-1989 with more than 10,000 patients being tested and a total of 513,368 injections being recorded. Our study showed that the probability of inducing systemic allergic reactions by skin testing was less than 0.02\% and the probability of systemic allergic reactions caused by immunotherapy was 2.9\%. The female to male ratio was 3 to 2. The highest incidence of systemic allergic reactions was in patients between the ages of 16 to 39 years of age. The majority of systemic allergic reactions occurred when patients were on increasing doses rather than maintenance doses. More than 95\% of systemic allergic reactions were associated with pollens and most of them happened between the concentration of 100 and 1000 PNU/mL. There was no increased incidence during grass or ragweed pollination seasons in those patients who received grass or ragweed injections during the respective seasons. Only 50\% of systemic allergic reactions developed within 30 minutes after injections. The three most important factors determining the incidence of systemic allergic reactions are the type of allergens, the "rate" of increase of allergen concentrations, and sensitivity of the patients to allergens. The prick test at initial allergy assessment can be used to "rule out," with a high degree of certainty, the likelihood of systemic allergic reactions. The prick test is easy to perform and it is cost-effective. Prick tests and RAST together are helpful in identifying the patients and the allergens at higher risk of systemic allergic reactions.
This article was published in Ann Allergy and referenced in Journal of Allergy & Therapy

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_he[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords