alexa Nonhalogenated solvent-based solvent evaporation process useful in preparation of PLGA microspheres.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Jang J, Sah H

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Abstract The objective of this study was to develop an isopropyl formate-based evaporation process useful in producing poly-D,L-lactide-co-glycolide microspheres. Surprisingly, the evaporating tendency of isopropyl formate was comparable to that of methylene chloride and far better than that of ethyl acetate. After optimization of the isopropyl formate-based process, progesterone was encapsulated into microspheres. Under our conditions, its encapsulation efficiency ranged from 75.1\% to 92.6\%. Even though all microspheres took spherical geometry, their external and internal morphologies were greatly influenced by progesterone payloads. A GC analysis demonstrated that residual isopropyl formate in various microspheres was 1.8\% to 4.0\%. Interestingly, progesterone underwent polymorphic transition during the microencapsulation process - the β form was present in microspheres with lower progesterone payloads, whereas the α form predominated over the β one at higher progesterone loads. In terms of human safety and environmental toxicity, isopropyl formate might have an edge over halogenated organic solvents for solvent evaporation. This article was published in J Microencapsul and referenced in Journal of Nanomedicine & Nanotechnology

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