alexa Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Masur K, Niggemann B, Zanker KS, Entschladen F

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Abstract Beta-adrenoceptors are highly expressed on SW 480 colon carcinoma cells as was assessed by flow cytometry. We investigated the influence of norepinephrine on the migration of these cells using time-lapse videomicroscopy. Norepinephrine-treatment increased the locomotor activity within the population from 25\% spontaneously locomoting cells to 65\% locomoting cells. The beta1/2-blocker propranolol but not the beta1-blocker atenolol inhibited this increase. The intracellular signaling solely of norepinephrine-induced locomotion involved protein tyrosine kinase activity, whereas both spontaneous and norepinephrine-induced migration were reduced by inhibiting phospholipase Cgamma and protein kinase Calpha activity. In summary, norepinephrine-induced locomotion of SW 480 cells is beta2-adrenoceptor mediated and distinct from spontaneous locomotion concerning the PTK involvement.
This article was published in Cancer Res and referenced in Journal of Cell Science & Therapy

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