Author(s): Jain RK Aut
Anti-angiogenic therapy was proposed in 1971 as a means to treat solid tumors and in 1976 as a method of cancer prevention. Here we propose that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics. Two major problems currently plague the non-surgical treatment of malignant solid tumors. First, physiological barriers within tumors impede the delivery of therapeutics at effective concentrations to all cancer cells 1.