alexa Novel 3,5-diaryl pyrazolines and pyrazole as low-density lipoprotein (LDL) oxidation inhibitor.
Chemical Engineering

Chemical Engineering

Mass Spectrometry & Purification Techniques

Author(s): Jeong TS, Kim KS, Kim JR, Cho KH, Lee S,

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Abstract Compounds 4a-j and 5 were synthesized by cyclocondensation of 3a-j and hydrazine and showed significant LDL-antioxidant activities in the TBARS assay, the lag time of conjugated diene production, the relative electrophoretic mobility (REM) of ox-LDL, the apoB-100 fragmentation, and the macrophage-mediated LDL oxidation. Among compounds 4a-j and 5, 4a was found to be the most active compound as an inhibitor of LDL oxidation and 4a (IC50 = 0.1 microM) was 6-fold more potent than probucol (IC50 = 0.6 microM) in the TBARS assay. This article was published in Bioorg Med Chem Lett and referenced in Mass Spectrometry & Purification Techniques

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