alexa Novel GES IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria.


Journal of Biometrics & Biostatistics

Author(s): Vourli S, Giakkoupi P, Miriagou V, Tzelepi E, Vatopoulos AC,

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Abstract Two clinical isolates, an Escherichia coli and a Klebsiella pneumoniae, with decreased susceptibility to carbapenems were studied. This phenotype was associated with production of novel GES/IBC variant beta-lactamases, designated GES-3 (from E. coli) and GES-4 (from K. pneumoniae), exhibiting carbapenemase activity. Both enzymes possessed Ser at Ambler's position 170 instead of Gly found in the beta-lactamases GES-1 and IBC-1 that lack carbapenemase activity. Additionally, position 104 in GES-4 was occupied by a Lys as in IBC-1. bla(GES-3) and bla(GES-4) occurred as gene cassettes in the variable regions of class 1 integrons carried by plasmids. The structure of the GES-4-encoding integron was similar to that of previously described IBC-1 integrons. The GES-3-encoding integron was, most likely, truncated at the 3' conserved segment. Copyright 2004 Federation of European Microbiological Societies This article was published in FEMS Microbiol Lett and referenced in Journal of Biometrics & Biostatistics

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