alexa Novel quinone methides from Salacia kraussii with in vitro antimalarial activity.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Figueiredo JN, Rz B, Squin U

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Abstract Three novel quinone methides, i.e., 28-nor-isoiguesterin-17-carbaldehyde (1), 17-(methoxycarbonyl)-28-nor-isoiguesterin (2), and 28-hydroxyisoiguesterin (3), together with the known celastrol (5), pristimerin (6), and isoiguesterol (7), were isolated from the roots of Salacia kraussii (Celastraceae) by bioassay-guided fractionation. The structures of the compounds were determined by DEPT and 2D NMR techniques. The isolates showed antimalarial activity 30-50-fold greater than their cytotoxicity (in HT-29 cells) in vitro, and they showed an additive effect when combined with each other. In vivo, 2 was found to be inactive against blood stages of Plasmodium berghei in mice after oral and parenteral administration, and the compound was toxic with increasing concentrations. This article was published in J Nat Prod and referenced in Journal of Cytology & Histology

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