Author(s): Chen F, Wang D, Chen F, Wang D
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Abstract IMPORTANCE OF THE FIELD: Dental caries is one of the most common preventable childhood diseases; people are susceptible to this ailment throughout their lifetime. In the US, 90\% of late adolescents and young adults have dental caries, while 94\% of all dentate adults had evidence of treated or untreated coronal caries. Dental caries is often not self-limiting and without proper care can progress until the tooth is destroyed. AREAS COVERED IN THIS REVIEW: In this paper, the etiology of dental caries is briefly introduced. It is followed by a thorough review of patents and literatures on the recent development of various novel technologies for the prevention and treatment of dental caries. WHAT THE READER WILL GAIN: Recent advances in anti-plaque agents, including chemoprophylactic agents, antimicrobial peptides, vaccines, probiotics/replacement therapy and sugar substitutes, and remineralization agents including fluorides and casein phosphopeptides are analyzed. TAKE HOME MASSAGE: Both the discovery of new anti-caries agents and the development of dentotropic delivery systems will be the future focus of this research field.
This article was published in Expert Opin Ther Pat
and referenced in Journal of Food: Microbiology, Safety & Hygiene