alexa Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Chow CW, Rincn M, Cavanagh J, Dickens M, Davis RJ

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Abstract The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4. In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.
This article was published in Science and referenced in Journal of Clinical & Cellular Immunology

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