alexa Nucleotide sequence of a variant protein A of Staphylococcus aureus suggests molecular heterogeneity among strains.
General Science

General Science

Journal of Forensic Research

Author(s): Brgido Mde M, Barardi CR, Bonjardin CA, Santos CL, Junqueira ML, , Brgido Mde M, Barardi CR, Bonjardin CA, Santos CL, Junqueira ML,

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Abstract Protein A is a cell wall linked protein of Staphylococcus aureus that binds mammalian IgG. Although protein A displays high size heterogeneity among strains, cloning and sequencing of its gene from two strains had not shown a large difference in size. Here we report a third protein A gene sequence that shows a size variation relative to these two, due to deletions on both one IgG binding domain and a cell wall binding domain (region X). By analysis of the three sequences we were able to delineate a hypothetic model for region X domain evolution and discussed the origin of genetic variability within and without strains.
This article was published in J Basic Microbiol and referenced in Journal of Forensic Research

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