Author(s): Lossos A, Siegal T
Abstract Share this page
Abstract We retrospectively evaluated 42 consecutive cancer patients with numb chin syndrome (NCS). Breast cancer comprised 64\% of the primary tumors, and lymphoproliferative neoplasms comprised 14\%. A standard workup (including imaging of the brain, base of skull, and mandible, and CSF analysis) led to the diagnosis of a metastatic etiology in 89\% of the patients. Fifty percent of the patients had mandibular metastases, 14\% base-of-skull bone lesions, and 22\% leptomeningeal seeding. NCS was a late manifestation of malignancy, associated with disease progression in 67\% of the patients or heralding a relapse, which was often confined to the leptomeninges, in 31\%. Although various therapeutic strategies led to resolution of NCS, median survival after its diagnosis was 5 months when due to bone metastases and 12 months if associated with leptomeningeal seeding.
This article was published in Neurology
and referenced in Oral Health Case Reports