alexa Number of centromeric signals in micronuclei and mechanisms of aneuploidy.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Iarmarcovai G, Botta A, Orsire T

Abstract Share this page

Abstract Genome instability or changes in chromosome structure and number are important facets of oncogenesis. Aneuploidy is a major cause of human reproductive failure and plays a large role in cancer. It is therefore important that any increase in its frequency due to occupational exposure to mutagens and carcinogens should be recognized and controlled. In recent years, the cytokinesis-block micronucleus assay has emerged as a biomarker of chromosome/genome damage relevant to cancer. Fluorescent in situ hybridisation using human pancentromeric DNA probes discriminates between the presence of acentric chromosomal fragments and whole chromosomes in binucleated micronucleated lymphocytes. The separated analysis of centromeric micronuclei may improve the sensitivity of the micronucleus assay in detecting genotoxic effects and chromosome instability. Our previous findings suggest that aneugenic events leading to micronuclei (MN) containing a single centromere (C1+MN) and two or more centromeres (Cx+MN) may arise through different pathways. Chromosome migration impairment would lead to increased C1+MN frequency whereas centrosome amplification would induce Cx+MN with three or more centromeric signals. Additional studies that target cellular defects on the centrosome (microtubule nucleation, organization of the spindle poles, cell cycle progression) are required to better understand aneuploid cell production. This article was published in Toxicol Lett and referenced in Journal of Molecular Biomarkers & Diagnosis

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords