Author(s): Madsen BW, Edeson RO, Lam HS, Milne RK
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Abstract A FORTRAN computer program is described which enables solution of a set of partial differential equations describing synaptic transmission, including neurotransmitter diffusion, binding to receptors on the postsynaptic membrane with subsequent formation of open ion-conducting channels, and hydrolysis. Integration is performed with a widely available package (PDETWO), and flexibility is achieved through use of 6 user-specified routines. The reliability of solution was checked by comparison with an analytic solution for a diffusion-only model. Application of the program is illustrated with an analysis of miniature endplate current rise times.
This article was published in Neurosci Lett
and referenced in Journal of Applied & Computational Mathematics