alexa Nutrition: a major factor influencing immunity in the elderly.
Medicine

Medicine

Journal of Gerontology & Geriatric Research

Author(s): Lesourd B

Abstract Share this page

Abstract This paper reviews recent findings on immune ageing. Ageing per se affects mainly cell-mediated immunity: decreases in mature T-cells (CD3+) partly compensated with increases in less mature T-cells (CD2+CD3-) are observed. In addition antigen pressure throughout life induces increases in memory T-cells (CD45R0+) and borderline decreases in CD8+ subsets. Those changes lead to lower proliferative ability. In contrast B-cell subsets and innate immunity are less affected with ageing. These changes are mainly related to health status and are less important in very healthy elderly. Such changes are more important in undernourished elderly, and in elderly who exhibit decreases in micronutrient status. They are even stronger in elderly patients with protein energy malnutrition (PEM). In seniors with PEM, decreased immune functions, for all aspects of immunity, i.e. T-cell, B-cell subsets and functions and innate immunity, are strongly related to protein nutritional status. Refeeding can boost immune response but at a lower speed in patients exhibiting inflammatory process. The disequilibrium between normal macrophage functions and decreased T-cell functions is partly responsible for long-lasting inflammatory process in stressed patients. Therefore acute phase responses are more detrimental on nutritional status and nutrient reserves in aged patients than in adults. Such disequilibrium, stress after stress, pushes the elderly to frailty state.
This article was published in J Nutr Health Aging and referenced in Journal of Gerontology & Geriatric Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version