alexa Observation of estimated GFR in the assessment of chronic kidney disease: Application and practice
Clinical Research

Clinical Research

Journal of Clinical Research & Bioethics

Author(s): D S S K Raju, D L Lalitha, Patnala Kiranmayi

Abstract Share this page

Staging of Chronic kidney disease (CKD) is important not only for proper evaluation and treatment but also to consider the need for dialysis. This staging depends on GFR value which is measured by radio labeled substances and 24 hours urine creatinine clearance but these have their own limitations. Serum creatinine based estimated GFR (eGFR) is more convenient and cost effective. Therefore this study was undertaken to estimate GFR by using Cockcroft-Gault formula, MDRD equation and MCQE in controls and CKD patients. The study comprised of 123 healthy individuals as control group and 128 patients with evidence of CKD. In control group, MCQE provided a reasonable value of eGFR in all age groups when compared with CG and MDRD formulae. Besides this, MDRD provided a higher value of eGFR than CG in the age group of above 60 years. CG and MDRD placed in, around 50% of the control population under less than<90ml/min/1.73m 2 grading them all as stage 2 mostly and only a few as stage 3. MCQE placed only 10% of healthy individuals under stage 2. Therefore, MCQE more appropriately estimates GFR in control group than CG and MDRD. There is a significant decrease of estimated GFR by three formulae in CKD group when compared with control group. In CKD group, very few cases are under stage 2 whereas stage 3 comprises of 28.2%, 26% and 23% according to CG, MDRD and MCQE respectively. The distribution of stage 4 includes 32%, 28.2% and 27% and stage 5 includes 39%, 45.3% and 48% according to CG, MDRD and MCQE respectively. This reflects the fact that the GFR is underestimated in CKD group and the same might have happened in the controls too. However, with some reservation, MCQE in control and MDRD and MCQE in cases are found to be satisfactory in staging CKD in the present study.
  • To read the full article Visit
  • Subscription
This article was published in Asian Journal of Pharmaceutical and Clinical Research and referenced in Journal of Clinical Research & Bioethics

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords