alexa Occurrence of cathepsin D isozymes with different specificities in monkey skeletal muscle.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Tanji M, Kageyama T, Takahashi K

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Abstract Cathepsin D was highly purified from the skeletal muscle of Japanese monkey (Macaca fuscata fuscata) by a procedure including affinity chromatography on concanavalin A-Sepharose and pepstatin-Sepharose, and then resolved into ten isozymes (A through J) by isoelectric focusing. When examined for specificity toward oxidized insulin B chain, isozyme A was highly specific and cleaved exclusively the Leu15-Tyr16 bond, whereas isozyme F was less specific, cleaving the Leu15-Tyr16 and Glu13-Ala14 bonds, with slower cleavages at several other bonds. These results demonstrate for the first time the occurrence of isozymes with different specificities among cathepsin D isozymes obtained from a single source.
This article was published in Biochem Biophys Res Commun and referenced in Journal of Carcinogenesis & Mutagenesis

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