alexa Oct-4: gatekeeper in the beginnings of mammalian development.
Reproductive Medicine

Reproductive Medicine

Reproductive System & Sexual Disorders: Current Research

Author(s): Pesce M, Schler HR

Abstract Share this page

Abstract The Oct-4 POU transcription factor is expressed in mouse totipotent embryonic stem and germ cells. Differentiation of totipotent cells to somatic lineages occurs at the blastocyst stage and during gastrulation, simultaneously with Oct-4 downregulation. Stem cell lines derived from the inner cell mass and the epiblast of the mouse embryo express Oct-4 only if undifferentiated. When embryonic stem cells are triggered to differentiate, Oct-4 is downregulated thus providing a model for the early events linked to somatic differentiation in the developing embryo. In vivo mutagenesis has shown that loss of Oct-4 at the blastocyst stage causes the cells of the inner cell mass to differentiate into trophectoderm cells. Recent experiments indicate that an Oct-4 expression level of roughly 50\%-150\% of the endogenous amount in embryonic stem cells is permissive for self-renewal and maintenance of totipotency. However, upregulation above these levels causes stem cells to express genes involved in the lineage differentiation of primitive endoderm. These novel advances along with latest findings on Oct-4-associated factors, target genes, and dimerization ability, provide new insights into the understanding of the early steps regulating mammalian embryogenesis. This article was published in Stem Cells and referenced in Reproductive System & Sexual Disorders: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

  • Ines Bouaziz
    Water treatment containing organic compounds by coupling adsorption and electrochemical degradation at BDD anode: Sawdust adsorption performance for the treatment of dilute phenol solutions
    PPT Version | PDF Version
  • Peter S. Nyasulu
    Prevalence and risk factors associated with acquisition of Sexually Transmitted Infections among people living with Human Immunodeficiency Virus in Diepsloot settlement, Johannesburg, South Africa
    PPT Version | PDF Version
  • Beste Cubukcuoglu
    Beste-Cubukcuoglu-Antalya-International-University-Turkey-The-environmental-impact-evaluation-and-testing-of-sustainable-inorganic-binders-A-green-alternative-to-ordinary-Portland-cement
    PPT Version | PDF Version
  • Nisreen K Aref
    To compare serum leptin levels in obese women with polycystic ovary syndrome (PCOS) and normal ovulatory obese subjects in Saudi Arabia, and to evaluate the interrelationship between leptin concentration, sex hormones, and insulin resistance.
    PPT Version | PDF Version
  • Nasser Nadim
    Nasser-Nadim- Clalit-Health-Organization-Services-Israel- A-different-perspective-to-white-matte
    PPT Version | PDF Version
  • Soliman Khatib
    Analysis of volatile organic compounds in rats with dopaminergic lesion: possible application for early detection of Parkinson’s disease
    PPT Version | PDF Version
  • Habiba Shehu
    Habiba-Shehu-Study-of-the-selectivity-of-methane-over-carbon-dioxide-and-inert-gases-using-composite-inorganic-membranes
    PPT Version | PDF Version
  • Charles I. Tobin-West
    Determinants of HIV transmission and sexual risk practices among women of childbearing age in semi-urban communities of Rivers State, Nigeria
    PPT Version | PDF Version
  • Marisa Krairiksh
    Implementation of Nursing Service Strategies Supporting ASEAN Economic Community in the Year 2015 of Nursing Organizations in Thailand
    PPT Version | PDF Version
  • Simge Zeyneloglu
    The effects of women’s sexual satisfaction on their marital accordance, whose spouses implementing “coitus interruptus” as the family planning method
    PPT Version | PDF Version
  • Yongming Sang
    Genome-Wide Transcriptomes Integrate Animal Intra- and Inter-Organism Processes and Evoke the Ecoimmunological Concept in Animal Health
    PPT Version | PDF Version
  • Tanvir Ahmed
    Sexual partners and condom use attitude: Qualitative findings among injecting drug users in Hai Phong, Vietnam
    PPT Version | PDF Version
  • Yamina Andre
    Nanostructured self-assembled P3HT thin films and their application to enhance organic solar cell efficiency
    PPT Version | PDF Version
  • Elucir Gir
    Nasal colonization by microorganisms in nursing professionals in units specializing in HIV/AIDS
    PPT Version | PDF Version
  • Tea Koiava
    Antibiotics sensitivity of microorganism causing nosocomial infections
    PPT Version | PDF Version

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version