alexa Okra polysaccharides inhibit adhesion of Campylobacter jejuni to mucosa isolated from poultry in vitro but not in vivo
Microbiology

Microbiology

Clinical Microbiology: Open Access

Author(s): Christian Lengsfeld, Gerhard Faller, Andreas Hensel

Abstract Share this page

In a previous study, high-molecular glycosylated compounds (polysaccharides and glycoproteins) from the immature fruits of the okra plant, Abelmoschus esculentus (L.) MOENCH, were shown to have a strong in vitro antiadhesive activity against Helicobacter pylori, leading to an inhibition of the binding to mucosal epithelia from human stomach in situ. For a further evaluation of okra compounds, aqueous extracts and polysaccharides were investigated concerning antiadhesive effects against the adhesion of Campylobacter jejuni on intestinal epithelia from chicken. In an in vitro adhesion model with fluorescent-labelled C. jejuni, the bacterial adhesion was shown to occur predominantly on jejunum and colon tissue, but only to a low extend on stomach, ileum and caecum tissue. Under these in vitro conditions, isolated okra polysaccharides strongly inhibited the microbial adhesion to colonic tissue. Within a controlled in vivo infection study over 42 days with chicken broilers infected by C. jejuni and fed with okra aqueous extract (50 and 100 g/kg) no significant reduction in Campylobacter excretion was observed, indicating that intestinal decontamination is not possible by the oral application of these compounds.

This article was published in Anim. Feed Sci Technol and referenced in Clinical Microbiology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords