alexa On the Mechanism of T cell receptor down-modulation and its physiological significance.


Journal of Clinical & Cellular Immunology

Author(s): Escors D, Bricogne C, Arce F, Kochan G, Karwacz K

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Abstract Effective, long-lasting immune responses largely depend upon T cell reponses. Antigen-specific T lymphocytes are activated and differentiate into effector T cells after antigen presentation by professional antigen presenting cells (APCs). However, T cell responses are tightly regulated to prevent T cell hyperactivation which may end up in autoimmune pathology. One of these regulatory mechanisms is ligand-induced TCR down-modulation, a process by which TCRs are removed from the T cell surface shortly after engagement with their cognate antigenic peptide associated to MHC molecules on the APC. TCR down-modulation is a complicated process. Here we briefly describe the three main models that attempt to clarify this mechanism in the context of T cell activation and function.
This article was published in J Biosci Med and referenced in Journal of Clinical & Cellular Immunology

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