Author(s): Wilson PD, Lavker RM, Kligman AM
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Abstract Clinical and morphologic studies were made of 20 cases of guttate hypomelanosis. The sharply demarcated hypopigmented macules were present on both covered and exposed sites, excluding sunlight exposure as a cause. Skin surface replicas and biopsies showed no evidence of post-traumatic or post-inflammatory scarring. The stratum corneum had fewer cell layers, but no abnormalities of keratinization were observed. Light and electron-microscopic and histochemical studies showed only reduced numbers of hypoactive melanocytes. In no case were melanocytes completely absent, excluding vitiligo. Guttate hypomelanosis is a common disorder of unknown origin. The evidence indicates an age-related somatic mutation of melanocytes.
This article was published in Acta Derm Venereol
and referenced in Dermatology and Dermatologic Diseases