alexa On the RET PTC3 Rearrangements in Chernobyl- related Thyroid Cancer vs. Late Detection
Social & Political Sciences

Social & Political Sciences

Journal of Defense Management

Author(s): Sergei V Jargin

Abstract Share this page

Thyroid cancer had been rarely diagnosed in children and adolescents prior to the Chernobyl accident in the areas, where the contamination later occurred, so that there was a pool of neglected cases. Detection by the screening of advanced tumors, interpreted as aggressive radiogenic cancers, coincided with the peak of RET/PTC3 rearrangements. The hypothesis discussed here is that successive waves of thyroid cancer after the Chernobyl accident in people exposed to the fallout at an early age, each wave with different molecular and morphological features, were determined not by radiation but by changing modalities of screening and diagnostics, their improvement with time, and exhaustion by the screening of the pool of advanced cancers. The cohort of papillary thyroid carcinoma in children, diagnosed during the first decade after the Chernobyl accident, where RET/PTC3 was the most prevalent rearrangement type, has been exceptional in the more developed parts of the world: in most series, RET/PTC1 has been the most common type of RET/PTC rearrangement. Considering that the data on sporadic tumors are mainly from more developed countries, this must be caused by the averagely earlier tumor detection. In conclusion, RET/PTC chromosomal rearrangements in papillary thyroid carcinoma RET/PTC3 in particular, probably correlate with disease progression.

  • To read the full article Visit
  • Open Access
This article was published in International Journal of Cancer Research and Molecular Mechanisms and referenced in Journal of Defense Management

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords