alexa On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator
Engineering

Engineering

Biosensors Journal

Author(s): Jiangang Zhu, Sahin Kaya Ozdemir, YunFeng Xiao, Lin Li, Lina He, DaRen Chen, Lan Yang

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The ability to detect and size individual nanoparticles with high resolution is crucial to understanding the behaviour of single particles and effectively using their strong size-dependent properties to develop innovative products. We report real-time, in situ detection and sizing of single nanoparticles, down to 30 nm in radius, using mode splitting in a monolithic ultrahigh-quality-factor (Q) whispering-gallery-mode microresonator. Particle binding splits a whispering-gallery mode into two spectrally shifted resonance modes, forming a self-referenced detection scheme. This technique provides superior noise suppression and enables the extraction of accurate particle size information with a single-shot measurement in a microscale device. Our method requires neither labelling of the particles nor a priori information on their presence in the medium, providing an effective platform to study nanoparticles at single-particle resolution.

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This article was published in Nature Photonics and referenced in Biosensors Journal

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