Author(s): Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC, Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC, Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC, Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC
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Abstract Follicular lymphoma is the most common human B-cell malignancy in the United States and Western Europe. Most of the tumours contain t(14;18) chromosome translocations involving the human bcl-2 gene. Translocation of bcl-2 sequences from chromosome 18 into the transcriptionally active immunoglobulin locus at chromosome band 14q32 in B cells deregulates bcl-2 gene expression, resulting in the accumulation of high levels of bcl-2 messenger. Human bcl-2 transcripts generate two proteins, p26 bcl-2-alpha and p22 bcl-2-beta, by virtue of alternative splice-site selection. Both proteins have in common their first 196 NH2-terminal amino acids but share little similarity with other sequences in a data bank. Although the biological and biochemical functions of bcl-2 are unknown, recent subcellular localization studies indicate that p26 bcl-2-alpha associates with cellular membranes, consistent with a stretch of hydrophobic amino acids in its carboxy terminus. The bcl-2 gene may represent a novel oncogene having no known retroviral counterpart. Here we demonstrate the oncogenic potential of bcl-2 through a gene transfer approach.
This article was published in Nature
and referenced in Research & Reviews: Journal of Botanical Sciences