alexa Onset of analgesia with sodium ibuprofen, ibuprofen acid incorporating poloxamer and acetaminophen--a single-dose, double-blind, placebo-controlled study in patients with post-operative dental pain.
Orthopaedics

Orthopaedics

Orthopedic & Muscular System: Current Research

Author(s): Daniels S, Reader S, Berry P, Goulder M

Abstract Share this page

Abstract OBJECTIVE: To compare the onset of action and efficacy of sodium ibuprofen (ibuprofen sodium dihydrate) and ibuprofen acid incorporating poloxamer (ibuprofen/poloxamer) with that of acetaminophen and placebo in patients with post-operative dental pain. METHODS: A double-blind, randomised, placebo-controlled, active comparator, two-centre study assessing the analgesic efficacy of sodium ibuprofen (512 mg, equivalent to 400 mg ibuprofen acid), ibuprofen/poloxamer (containing 400 mg ibuprofen acid and 120 mg poloxamer 407), acetaminophen (1000 mg) and placebo in patients with moderate-to-severe pain after third molar extraction (n = 322). Onset of action was assessed using the two-stopwatch technique, and pain intensity and relief were measured using validated traditional descriptor scales. RESULTS: Significantly more patients achieved confirmed perceptible pain relief and meaningful pain relief with sodium ibuprofen (96.3\%, P < 0.0001) and ibuprofen/poloxamer (90.0\%, P = 0.0005) than with acetaminophen (67.5\%). The onset of action of both ibuprofen formulations was comparable with that of acetaminophen up to 45 min post-dose; a marked divergence in onset times in favour of the ibuprofen formulations occurred from 45 min onward. Mean values for the area under the pain relief and pain intensity differences curve (0-6 h) were significantly greater for sodium ibuprofen (3.46) and ibuprofen acid (3.49) than for acetaminophen (2.25) (P < 0.001). Other pain relief and pain intensity endpoints favoured both ibuprofen formulations over acetaminophen. Distractibility from pain (6 h) was significantly greater with the ibuprofen formulations than with acetaminophen (P = 0.008 for sodium ibuprofen; P = 0.03 for ibuprofen/poloxamer). In patients receiving ibuprofen, pain interfered less with daily activities (at 1 and 6 h) than in those receiving acetaminophen (P
  • DOI: 10.1007/s00228-009-0614-y
  • This article was published in Eur J Clin Pharmacol and referenced in Orthopedic & Muscular System: Current Research

    Relevant Expert PPTs

    Relevant Speaker PPTs

    Recommended Conferences

    Peer Reviewed Journals
     
    Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
    International Conferences 2017-18
     
    Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

    Contact Us

    Agri, Food, Aqua and Veterinary Science Journals

    Dr. Krish

    [email protected]

    1-702-714-7001 Extn: 9040

    Clinical and Biochemistry Journals

    Datta A

    [email protected]

    1-702-714-7001Extn: 9037

    Business & Management Journals

    Ronald

    [email protected]

    1-702-714-7001Extn: 9042

    Chemical Engineering and Chemistry Journals

    Gabriel Shaw

    [email protected]

    1-702-714-7001 Extn: 9040

    Earth & Environmental Sciences

    Katie Wilson

    [email protected]

    1-702-714-7001Extn: 9042

    Engineering Journals

    James Franklin

    [email protected]

    1-702-714-7001Extn: 9042

    General Science and Health care Journals

    Andrea Jason

    [email protected]

    1-702-714-7001Extn: 9043

    Genetics and Molecular Biology Journals

    Anna Melissa

    [email protected]

    1-702-714-7001 Extn: 9006

    Immunology & Microbiology Journals

    David Gorantl

    [email protected]

    1-702-714-7001Extn: 9014

    Informatics Journals

    Stephanie Skinner

    [email protected]

    1-702-714-7001Extn: 9039

    Material Sciences Journals

    Rachle Green

    [email protected]

    1-702-714-7001Extn: 9039

    Mathematics and Physics Journals

    Jim Willison

    [email protected]

    1-702-714-7001 Extn: 9042

    Medical Journals

    Nimmi Anna

    [email protected]

    1-702-714-7001 Extn: 9038

    Neuroscience & Psychology Journals

    Nathan T

    [email protected]

    1-702-714-7001Extn: 9041

    Pharmaceutical Sciences Journals

    John Behannon

    [email protected]

    1-702-714-7001Extn: 9007

    Social & Political Science Journals

    Steve Harry

    [email protected]

    1-702-714-7001 Extn: 9042

     
    © 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
    adwords