alexa Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Cirillo LA, Lin FR, Cuesta I, Friedman D, Jarnik M,

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Abstract The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the albumin gene enhancer in liver precursor cells in embryos. To understand how they access sites in silent chromatin, we assembled nucleosome arrays containing albumin enhancer sequences and compacted them with linker histone. HNF3 and GATA-4, but not NF-1, C/EBP, and GAL4-AH, bound their sites in compacted chromatin and opened the local nucleosomal domain in the absence of ATP-dependent enzymes. The ability of HNF3 to open chromatin is mediated by a high affinity DNA binding site and by the C-terminal domain of the protein, which binds histones H3 and H4. Thus, factors that potentiate transcription in development are inherently capable of initiating chromatin opening events.
This article was published in Mol Cell and referenced in Journal of Carcinogenesis & Mutagenesis

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