Author(s): Pert CB, Snyder SH
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Abstract Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue.
This article was published in Science
and referenced in Journal of Addiction Research & Therapy