Author(s): Zagon IS, McLaughlin PJ
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Abstract Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20 Y neuroblastoma (NB) in A/Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69\% tumor take, 70\% delay in time prior to tumor appearance, and a 60\% increase in median survival time. Inoculation of NB in control mice resulted in 100\% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.
This article was published in Cancer Lett
and referenced in Journal of Clinical & Experimental Pharmacology