alexa Opioid hyperexcitability: the application of alternate opioid therapy.
Chemical Engineering

Chemical Engineering

Journal of Analytical & Bioanalytical Techniques

Author(s): MacDonald N, Der L, Allan S, Champion P

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Abstract Three cases are reported where patients experienced severe central nervous system adverse effects on high-dose hydromorphone. These effects were rapidly alleviated following a change in therapy to morphine at 20-25\% of the usually accepted potency equivalent dose. We recommend caution in using equivalent dose tables when changing opioid therapy in patients receiving high-dose opioid treatment.
This article was published in Pain and referenced in Journal of Analytical & Bioanalytical Techniques

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