alexa Optimal management of β thalassaemia intermedia.
Nursing

Nursing

Advanced Practices in Nursing

Author(s): Taher AT, Musallam KM, Cappellini MD, Weatherall DJ, Taher AT, Musallam KM, Cappellini MD, Weatherall DJ

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Abstract Our understanding of the molecular and pathophysiological mechanisms underlying the disease process in patients with β thalassaemia intermedia (TI) has substantially increased over the past decade. The hallmark of disease process in patients with TI includes ineffective erythropoiesis, chronic haemolytic anaemia, and iron overload. There are a number of options currently available for managing patients with TI including splenectomy, transfusion therapy, iron chelation therapy, modulation of fetal haemoglobin production, and several other agents targeting specific clinical complications. Limited studies assessed the efficacy and safety of these modalities; hence, there are currently no clear guidelines for managing patients with TI. Until solid evidence-based guidelines are available, individualised treatment should be entertained. © 2011 Blackwell Publishing Ltd. This article was published in Br J Haematol and referenced in Advanced Practices in Nursing

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