alexa Oral and serum IL-6 levels in oral lichen planus patients.

Journal of Autacoids and Hormones

Author(s): Gu GM, Martin MD, Darveau RP, Truelove E, Epstein J

Abstract Share this page

Abstract OBJECTIVE: The purpose of this study was to compare IL-6 levels in oral exfoliated mucosal cell samples and in serum in subjects with oral lichen planus versus controls. Study design Ten patients with ulcerative OLP, 10 with reticular OLP, and 10 control subjects were recruited at a University Oral Medicine Clinic. Using smear tissue culture brushes, oral samples were collected from lesional sites for OLP patients and from buccal mucosa for controls into vials with 300 muL PBS. After centrifugation, the supernatants were aspirated for cytokine ELISA assay and protein assay. Venous blood was processed to serum for ELISA assay. Oral IL-6 was expressed as both pg/mL and pg/mug protein, and serum IL-6 was expressed as pg/mL. RESULTS: The mean oral IL-6 levels were higher in the ulcerative OLP group (11.19 +/- 5.34 pg/mL) than in the reticular OLP (1.05 +/- 0.34 pg/mL) and control (0.52 +/- 0.29 pg/mL) groups. There were significant differences between ulcerative OLP and reticular OLP groups (P < .039), and between ulcerative OLP and control groups (P < .009). After the standardization of IL-6 concentration by protein, a significant difference in IL-6 concentration was shown only between the ulcerative OLP (0.0245 +/- 0.0121 pg/mug protein) and control (0.0023 +/- 0.0012 pg/mug protein) groups (P < .029). Similarly, the ulcerative OLP group showed a significantly higher serum IL-6 level than the control group (P < .021). CONCLUSION: Both oral and serum IL-6 levels were higher in patients with ulcerative OLP. An oral exfoliated cell technique may be a useful and sensitive method to measure IL-6 in patients with OLP as it provided results consistent with those found in peripheral blood. This article was published in Oral Surg Oral Med Oral Pathol Oral Radiol Endod and referenced in Journal of Autacoids and Hormones

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords