alexa Oral human papillomavirus in healthy individuals: a systematic review of the literature.


Molecular Biology: Open Access

Author(s): Kreimer AR, Bhatia RK, Messeguer AL, Gonzlez P, Herrero R,

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Abstract BACKGROUND: Human papillomavirus type 16 (HPV16) is a common infection in the anogenital tract. HPV16 DNA detected in oral specimens has recently been identified as a risk factor for some oropharyngeal cancers. The reported prevalence of oral HPV infection from individual studies is highly variable. METHODS: We systematically reviewed and abstracted data from published studies (n = 18) that detected oral HPV DNA in 4581 cancer-free subjects to determine the pooled prevalence (and 95\% confidence intervals [CI]) of HPV16, carcinogenic HPV, and any HPV. RESULTS: 1.3\% (95\% CI: 1.0-1.7\%) of 3977 healthy subjects had oral HPV16, 3.5\% (95\% CI: 3.0-4.1) of 4441 subjects had carcinogenic HPV, and 4.5\% (95\% CI: 3.9-5.1) of 4070 subjects were positive for any HPV. Oral HPV16 accounted for 28\% of all HPV detected in the oral region. Men (47 of 1017) and women (117 of 3690) had nearly exactly the same prevalence of any oral HPV detected (4.6\% vs. 4.4\%, respectively). CONCLUSIONS: HPV-16, a common anogenital infection, was rarely detected in oral specimens. However, a small but noteworthy proportion of healthy individuals have oral HPV infections with types known to cause cancer in the oral region. This article was published in Sex Transm Dis and referenced in Molecular Biology: Open Access

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